Ford JA, et al. - A sum of 340 candidates were studied to assess the risk of succession to rheumatoid arthritis (RA) in subjects who were cyclic citrullinated antibody positive (CCP+) without RA initially. Authors observed the development of RA in 21.5% of candidates during 1047 person-years of follow-up. They also noticed an incline in the risk of progression to RA with CCP level, with 46.0% of high-level CCP subjects improving to RA by 5 years. Adjusting for age, sex, body mass index, smoking, family history of RA, and rheumatoid factor level, medium and high CCP levels were strongly correlated with progression to RA when compared to low CCP.