Feurer E, et al. - From the OFELY Cohort, researchers conducted cross-sectional and longitudinal analyses to study the serum levels of 32 preselected microRNAs (miRNAs) with reported function in bone and their correlation with osteoporotic fracture. By qRT-PCR, serum levels of the miRNAs were quantified in 682 women: 99 premenopausal and 583 postmenopausal women, with 1 and 122 women with prevalent fragility fractures in each group. No evidence that these 32 preselected miRNAs were not related to bone turnover markers (BTMs), BMD, microarchitecture, and or fragility fractures (prevalent or incident) was found in a well-characterized prospective cohort with sizeable sample size.