Abeles RD, et al. - Via performing a retrospective derivation (2008-2016, 356 patients) and a prospective validation (2016- 2017, 111 patients) non-alcoholic fatty liver disease (NAFLD) cohort study, researchers studied if elevated mean platelet volume (MPV) was associated with increased risk of cardiovascular events in NAFLD patients and whether its inclusion in a cardiovascular risk score for NAFLD patients would identify patients at higher risk of major acute cardiovascular events (MACE) vs current standard cardiovascular risk score. Investigators found that patients with NAFLD and a NAFLD CV score of more than −3.98 or an MPV greater than 10.05 were at high risk of MACE (Cardiovascular death, acute coronary syndrome, stroke and transient ischaemic attack) within 12 months. According to findings, the NAFLD CV risk score and MPV predict 1-year risk of MACE precisely, thus enabling better identification of patients requiring optimization of their cardiovascular risk profile.