Kim K, et al. - In this retrospective, propensity score-matched study, researchers investigated whether cardiovascular risk and all-cause death in individuals aged >75 years were attenuated effectively by using statin for primary prevention. Participants were 1559 statin-naïve patients without a history of atherosclerotic cardiovascular disease before the index visit. The final analysis was performed in 1278 patients (639 statin users, 639 statin non-users) following propensity score matching, with a focus on major adverse cardiovascular and cerebrovascular events (MACCE; including cardiovascular death, nonfatal myocardial infarction, coronary revascularization, and nonfatal stroke or transient ischemic attack) and all-cause death. In individuals aged >75 years, an attenuated risk of cardiovascular events and all-cause death was observed in association with statin therapy for primary prevention. Based on these findings, it was considered beneficial to ensure more active statin use in this population.