Elmarsafi T, et al. - Researchers studied 331 candidates to quantify the risk factors for major lower extremity amputations (LEAs) among cases who experienced osseous Charcot reconstruction. They observed that all the subjects requiring osseous reconstruction had diabetes, neuropathy, or Charcot neuroarthropathy (CN). They recorded odds ratios (ORs) of respective risk factors: postoperative nonunion (OR 8.5), development of new site of CN (OR 8.2), peripheral arterial disease (OR 4.3), renal disease (OR 3.7), postoperative delayed healing (OR 2.6), postoperative osteomyelitis (OR 2.4), or elevated glycated hemoglobin. For the long-term prevention of major amputations, independent risk factors found to be statistically significant for major LEA in diabetic CN in setting osseous reconstruction must be mitigated.