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Clinicopathologic features, incidence and survival trends of gynecologic neuroendocrine tumors; A SEER data base analysis

American Journal of Obstetrics and Gynecology Mar 10, 2019

Gibbs J, et al. - Using Surveillance, Epidemiology and End Results (SEER) cancer registry, researchers assessed the clinicopathologic features, incidence and survival trends in gynecological neuroendocrine tumors (gNET). For this investigation, data were extracted regarding stage, grade, presence of extrauterine disease, receipt of adjuvant radiation, surgical intervention, incidence and overall survival. For statistical analysis, Chi-square tests, Pearson Correlation and Kaplan Meir curves were used. During the study period, 559 cases (242 cervical, 160 ovarian, 118 uterine and 39 vulvar/vaginal) of gNET were identified. According to results, poorly differentiated tumors accounted for 65.0% of cervical tumors, 45.3% of ovarian tumors, and 57.4% of uterine tumors. Investigators found that neuroendocrine tumors of the gynecologic tract are uncommon aggressive malignancies. These poorly differentiated tumors with a high incidence of extrauterine disease are present at an advanced stage. Despite 25 years of advances in cancer therapy, no improvement in overall survival was observed.
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