Haywood ST, et al. – Given the significantly improved morbidity and mortality rates with non-invasive positive-pressure ventilation (NIPPV) for managing respiratory failure (RF) secondary to acute decompensated heart failure (ADHF), researchers investigated high-velocity nasal insufflation (HVNI) vs NIPPV for the treatment of RF secondary to ADHF regarding therapy failure—as indicated by the requirement for intubation or all-cause arm failure including subjective crossover to the alternate therapy. In this subgroup analysis from a larger randomized control trial that included adults presenting to the emergency department with RF requiring NIPPV support, 22 HVNI and 20 NIPPV patients were included. Outcomes suggested non-inferiority of HVNI to NIPPV for patients with RF secondary to ADHF that do not need emergent intubation.