Coll-de-Tuero G, et al. - In 2,516 hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m², researchers investigated the link between the rate and intensity of eGFR decline is linked to cardiovascular risk and death. Participants had at least two serum creatinine measurements over a four-year period. The outcomes of interest were coronary artery disease, stroke, transitory ischemic accident, peripheral arterial disease, heart failure, atrial fibrillation, death from any cause. They performed Cox regression analyses adjusted for potentially confounding factors. High-eGFR decline was defined as an eGFR attenuation of ≥10% per year; low decline was defined as a reduction in eGFR of less than 10% per year. This study included 2,354 patients with low rate of eGFR decline and 149 with high-rate of eGFR decline. For patients with arterial hypertension without chronic kidney disease at baseline, CV risk was designated by a rate of eGFR decline of -10% or more per year. Possible utility of intensifying the global risk approach for these patients was also suggested.