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Control of blood pressure and risk of mortality in a cohort of older adults: The Berlin Initiative Study

European Heart Journal Mar 08, 2019

Douros A, et al. - In community-dwelling older adults within the Berlin Initiative Study, researchers investigated if blood pressure (BP) values lower than 140/90 mmHg during antihypertensive treatment were related to an attenuated risk of all-cause mortality. Participants were ≥70 years treated with antihypertensive drugs at baseline (November 2009-June 2011). They used Cox proportional hazards models and estimated adjusted hazard ratios and 95% confidence intervals for all-cause mortality related to normalized BP (systolic BP <140 mmHg and diastolic BP <90 mmHg) vs non-normalized BP (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) overall and following stratification by age or previous cardiovascular events. Normalized BP was present in 636 of 1,628 patients (mean age 81 years) who were receiving antihypertensive drugs. In octogenarians or elderly patients with prior cardiovascular events, an higher risk of mortality could be seen in relation to blood pressure values below 140/90 mmHg during antihypertensive treatment.

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