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Detection efficacy of 18F-PSMA-1007 PET/CT in 251 patients with biochemical recurrence of prostate cancer after radical prostatectomy

The Journal of Nuclear Medicine Mar 07, 2019

Giesel FL, et al. - After radical prostatectomy, researchers studied the diagnostic effectiveness of 18F-prostate-specific membrane antigen (PSMA)-1007 for biochemical recurrence (BCR). In a retrospective analysis, 251 patients with BCR were assessed following radical prostatectomy in one of three academic centers. Previous exposure to first-line ADT was permitted, but patients with second-line androgen deprivation therapy or chemotherapy were excluded. Of the 251 patients, on 18F-PSMA-1007 PET/CT, 204 (81.3%) had evidence of recurrence. According to findings, 18F-PSMA-1007 PET/CT provides high detection rates for BCR following radical prostatectomy similar to or better than those published for 68Ga-labeled PSMA ligands.

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