Staszewski J, et al. - In patients with acute ischemic stroke (AIS) after recombinant tissue plasminogen activator (rt-PA) treatment, researchers examined the predictive value of mean platelet volume (MPV) for short-term functional outcome. They retrospectively analyzed 237 AIS patients and identified with a mean MPV of 9.8±0.35 fL (lowest tertile 8.8 fL) consecutively admitted to a tertiary care center between 2011 and 2015. Compared to patients in the median and highest tertiles, those in the lowest tertile were dependent at admission less frequently and had a poor stroke outcome (modified Rankin scale [mRS] 4–6) at discharge less frequently. Thrombolyzed patients with high admission MPV had disabling or fatal ischemic stroke more frequently. MPV had a prognostic value independent of other well-defined individual risk factors.