Simonsson M, et al. - From 2009 to 2014, authors examined 97,597 subjects with acute myocardial infarction to develop and verify a new in-hospital bleeding risk score for such cases. They recorded 1356 patients with in-hospital major bleeding (fatal, intracranial, or wanting surgery or blood transfusion). They calculated 5 predictors in the approximate model constituting the SWEDEHEART score: hemoglobin, age, sex, creatinine, and C-reactive protein. A higher discriminative ability as compared to both recalibrated scores, overall (C-index 0.80 vs 0.73/0.72) and in all predefined subgroups was observed in the SWEDEHEART score. A consistently positive and higher net benefit for the SWEDEHEART score corresponded with both recalibrated scores across all clinically associated decision thresholds was illustrated by decision curve analysis.