Wang T, et al. – In some studies, negative pressure wound therapy offered significant clinical benefits in the healing of diabetic foot wounds. Thus, researchers of the current study examined the mechanism of regulation of MAPK-JNK signaling pathway by negative pressure wound therapy on these wounds. Investigators found that the level of tumor necrosis factor-α, interleukin-6, and P-c-Jun N-terminal kinase decreased significantly. There was, however, no statistical difference in the expression of p38, extracellular signal regulated kinase1 and 2 in messenger ribonucleic acid. In diabetic foot patients, negative pressure wound therapy may suppress the wound inflammation by inhibiting interleukin-6, tumor necrosis factor-α, and inducible nitric oxide synthase. This effect may be mediated by suppressing the MAPK-JNK signaling pathway, at least in part.