Gersing AS, et al. - In this investigation, researchers studied changes in the composition of knee cartilage in overweight and obese participants with constant weight vs those with weight loss over 96 months, and evaluated how different weight loss regimens are associated with these changes. The study sample consisted of 760 participants from the Osteoarthritis Initiative with baseline body mass index measures of > 25kg/m² who also either had risk factors for or mild to moderate knee osteoarthritis. Their right knees were assessed for knee cartilage composition. In the diet and diet and exercise groups, slower increases in global T2 were observed vs the stable weight (SW; n=380) group, but not only in the group exercise. According to findings, weight loss can slow knee cartilage degeneration over 96 months and may vary by weight loss method.