Zou PY, Hu J, Zhao JT, et al. - Researchers conducted a retrospective study examining if eradication rates for Helicobacter pylori differ by high-dose dual therapy (HDDT) with different regimens. The efficacy and safety of HDDT 10-day vs 14-day were compared and the factors that might impact the eradication rates were investigated. Propensity score matching (PSM) was done to retrieve two comparable treatment groups. Based on the therapy received, division of patients was done into two groups: 10-day HDDT and 14-day HDDT (20 mg esomeprazole and 750 mg amoxicillin, administered four times daily). Outcomes revealed a higher H. pylori eradication rate in correlation with the 14-day HDDT vs the 10-day HDDT.