• Profile
Close

Waist size, not body mass index, may be more predictive of coronary artery disease

The North American Menopause Society News Aug 30, 2019

For years, women have been told that weight gain could lead to heart disease. A new study indicates that it is the location of the fat that matters most, with abdominal fat representing the greatest harm and not overall body mass index (BMI) when assessing risk for coronary artery disease (CAD). Results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).

Because CAD remains the leading cause of death worldwide, there is tremendous attention given to its modifiable risk factors. Estrogen protects women’s cardiovascular systems before menopause, which helps explain why the incidence of CAD in premenopausal women is lower than in men. However, as women’s estrogen levels decline during and after menopause, the incidence of CAD in postmenopausal women outpaces similarly aged men.

Obesity has long been known as a risk factor for CAD because it causes endothelial cell dysfunction, insulin resistance, and coronary atherosclerosis, among other problems. It also is often accompanied by other cardiovascular risk factors, such as hypertension and diabetes. In the past, it has been suggested that overall obesity (which is often defined by BMI) is a primary risk factor. Few studies have attempted to compare the effect of overall obesity vs central obesity, which is typically described by waist circumference and/or waist-to-hip ratio.

The results of this new study of nearly 700 Korean women, however, demonstrated that the presence of obstructive CAD was significantly higher in women with central obesity. No significant difference was identified based on BMI, indicating that overall obesity was not a risk factor for obstructive CAD. These results are especially relevant for postmenopausal women because menopause causes a change in body fat distribution, especially in the abdominal area.

Findings were published in the article “Association between obesity type and obstructive cardiovascular disease in stable symptomatic postmenopausal women: data from the KoRean wOmen’S chest pain rEgistry (KoROSE). “The findings of this study are consistent with what we know about the detrimental effects of central obesity. Not all fat is the same, and central obesity is particularly dangerous because it is associated with risk for heart disease, the number one killer of women. Identifying women with excess abdominal fat, even with a normal BMI, is important so that lifestyle interventions can be implemented,” says Dr. Stephanie Faubion, NAMS medical director.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay