Sun effects on skin reveal eczema therapy clues
University of Edinburgh College of Medicine News Jul 08, 2017
Exposure to sunlight releases a compound from the skin that can alleviate symptoms of eczema, research has found.
The molecule  called nitric oxide  works by dampening inflammation, which causes the itchy skin lesions associated with the condition.
Scientists say their findings pave the way for new therapies that mimic the effects of the sunÂs rays.
These could eventually help patients avoid light therapy, which can have damaging side effects on the skin, including raising cancer risk.
Tests on healthy volunteers found that exposing a small patch of skin to UV light triggers nitric oxide to be released into the blood stream.
Further lab studies found that the chemical activates specialised immune cells called regulatory T cells, which act to dampen ongoing inflammation.
"Our findings suggest that nitric oxide has powerful anti–inflammatory properties and could offer an alternative drug target for people with eczema," said lead researcher Dr Anne Astier from MRC Centre for Inflammation Research, University of Edinburgh.
In patients with eczema, the number of these cells in their blood following light therapy directly correlates with disease improvement, the University of Edinburgh team found. Researchers say their findings could lead to new therapies for eczema, which affects around one in five children and one in 20 adults in the UK.
People with severe eczema are often prescribed tanning lamps to help manage their symptoms, but these can cause skin burning, accelerated aging and increased risk of cancer.
The study was published in the Journal of Allergy and Clinical Immunology.
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The molecule  called nitric oxide  works by dampening inflammation, which causes the itchy skin lesions associated with the condition.
Scientists say their findings pave the way for new therapies that mimic the effects of the sunÂs rays.
These could eventually help patients avoid light therapy, which can have damaging side effects on the skin, including raising cancer risk.
Tests on healthy volunteers found that exposing a small patch of skin to UV light triggers nitric oxide to be released into the blood stream.
Further lab studies found that the chemical activates specialised immune cells called regulatory T cells, which act to dampen ongoing inflammation.
"Our findings suggest that nitric oxide has powerful anti–inflammatory properties and could offer an alternative drug target for people with eczema," said lead researcher Dr Anne Astier from MRC Centre for Inflammation Research, University of Edinburgh.
In patients with eczema, the number of these cells in their blood following light therapy directly correlates with disease improvement, the University of Edinburgh team found. Researchers say their findings could lead to new therapies for eczema, which affects around one in five children and one in 20 adults in the UK.
People with severe eczema are often prescribed tanning lamps to help manage their symptoms, but these can cause skin burning, accelerated aging and increased risk of cancer.
The study was published in the Journal of Allergy and Clinical Immunology.
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