• Profile
Close

Researchers verify new method of HIV transmission among injection drug users and effective prevention technique

ScienceDaily May 01, 2019

New studies from Lawson Health Research Institute and Western University have found for the first time that HIV can be transmitted through the sharing of equipment used to prepare drugs before injection and that a simple intervention—heating the equipment with a cigarette lighter for 10 seconds—can destroy the HIV virus, preventing that transmission. The findings, used to inform a public health campaign called "Cook Your Wash," have helped reduce rates of HIV transmission in London, Ontario, Canada.

The two studies published in Journal of Acquired Immune Deficiency Syndrome (JAIDS) were initiated in 2016 to address a public health emergency in London, Ontario, when HIV rates among injection drug users more than doubled.

"This outbreak occurred despite London having Canada's largest per capita sterile needle and syringe distribution program, a strong opiate substitution therapy program, and a multidisciplinary HIV clinic," says Dr. Michael Silverman, Lawson associate scientist and chair/chief of infectious diseases at the Schulich School of Medicine & Dentistry, Western University, London Health Sciences Centre and St. Joseph's Health Care London. "We knew there must be a novel method of HIV transmission at play."

From August 2016 to June 2017, the research team interviewed 119 injection drug users to understand their injection behaviors and risk for HIV. They discovered that those who shared equipment used to prepare drugs for injection were 22 times more likely to contract HIV than those who did not, despite not sharing needles or syringes.

The equipment includes a metal "cooker" used to dissolve drugs in water and a filter used to draw the mixture, known as "the wash," into the syringe. Injection drug users reported reusing the equipment when consuming controlled-release hydromorphone, one of the most commonly injected opioids.

"Controlled-release hydromorphone is expensive and difficult to dissolve. After the first wash, large amounts of the drug remain in the equipment which is then saved, shared, or sold for future use," explains Dr. Sharon Koivu, associate scientist at Lawson and associate professor at Schulich Medicine & Dentistry. "While people know not to share needles, some use their own needle multiple times, allowing for contamination of the equipment."

The team took their findings back to the research laboratory. They confirmed that, on average, 45% of the drug remains in the equipment after the first wash. They not only confirmed the HIV virus can be transmitted between needles, cookers, and filters, but also discovered that controlled-release hydromorphone has properties that promote survival of the virus.

"The slow-release properties in the drug can unfortunately stabilize the HIV virus," says Eric Arts, PhD, chair of the Department of Microbiology and Immunology at Schulich Medicine & Dentistry. "For the first time, we were able to demonstrate that sharing equipment could lead to the type of HIV outbreak we observed in the community."

The team discovered that when the cooker is heated with a cigarette lighter for approximately 10 seconds, or until the wash bubbles, the virus is destroyed. They termed the technique "cook your wash."

They also confirmed that heating the cooker did not impact drug concentration. "We had to make sure that cooking your wash would not change the amount of drug being drawn into the syringe," notes Dr. Silverman. "If too much drug was released, it could lead to overdoses. If any drug was burnt off or lost, the intervention would not be accepted by persons who inject drugs."

Partnering with local community organizations like the Middlesex-London Health Unit and Regional HIV/AIDS Connection, "Cook Your Wash" was launched as a public health campaign.

"The 'Cook Your Wash' campaign is one of the most exciting things to happen in our community," says Dr. Koivu. "We learned from persons who inject drugs, took that information to the lab to develop a solution, and then brought that solution back to the community in record time."

Dr. Silverman adds that local rates of new HIV cases fell dramatically after the introduction of the campaign. "It wasn't the sole reason for the reduction in HIV rates as other interventions were also introduced, but the timing suggests it was part of the solution."

The studies build on previous research that shows sharing equipment can lead to the transmission of hepatitis C, and controlled-release hydromorphone can promote the survival of bacteria that can cause endocarditis, which is an infection of the heart valves.

The team hopes this research can be used to inform understanding and interventions in other centers facing HIV epidemics among persons who inject drugs. "We hope our findings can be used to reduce the incidence of HIV transmissions even further and that, one day, society will be HIV free," says Dr. Silverman.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay