• Profile
Close

Researchers create new model to better understand, treat metabolic diseases

MedicalXpress Breaking News-and-Events Jun 22, 2022

While it has been more than 100 years since the discovery of insulin, metabolic diseases like diabetes, obesity and fatty liver continue to impact most of the population. More than one-third (36.5 per cent) of adults in the U.S. have obesity while another 32.5 per cent of American adults are overweight. In all, more than two-thirds of adults in the United States are overweight or have obesity.

Metabolic syndrome is a cluster of conditions that occur together, increasing one's risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol or triglyceride levels. Despite extensive study and experimentation, researchers have not yet figured out how to prevent or reverse these conditions.

Now a group of researchers from Boston University School of Medicine (BUSM), the University of Wisconsin, Yale School of Medicine and the University of Montreal have devised a new testable model that may lead to a better understanding and treating metabolic diseases.

"Progress requires models that can inform our understanding. The current models are inadequate and therefore not likely to help solve this important problem. A revised model is needed," says co-corresponding author Barbara E. Corkey, PhD, professor emeritus of medicine and biochemistry at BUSM.

In this review article, the researchers integrate many new aspects of cell metabolic signal transduction (the process by which a cell responds to substances outside the cell through signalling molecules found on the surface of and inside the cell) that has previously not been covered with new knowledge in the field. From this analysis, the researchers have developed a new testable model.

According to the researchers, this area of study addresses a central question in metabolism at large: how do calorigenic nutrients activate a cell? "This is important not only for the diabetes field but also for many other systems such [as] the fuel-sensitive cells in the gut, the portal vein and the brain," says Corkey.

These findings appear online in the journal Cell Metabolism.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay