An enzyme called diacylglycerol kinase zeta (DGKζ) appears to play an important role in suppressing runaway inflammation in asthma and may represent a novel therapeutic target, according to research presented at ATS 2019. The researchers deleted the enzyme in mouse T cells, which drive the immune system, and found that both inflammation and airway hyper-responsiveness, two hallmarks of asthma, were reduced through independent biomolecular mechanisms.