The use of echocardiography, which creates two-dimensional images of the heart, can help clinicians better predict outcomes for individuals with pulmonary embolisms, says a Yale author of a new study.

Acute pulmonary embolism is a serious, potentially fatal condition in which a clot impedes blood flow in pulmonary arteries. Increasingly, clinicians have used echocardiography in these patients to assess structural and functional changes to the heart.

To study the impact of using echocardiography for assessing pulmonary embolisms, the study authors analyzed data from RIETE, a large international registry of patients with the condition, from 2001 to 2017. They observed that among 35,935 patients, 15,375 (42.8%) underwent early echocardiographic assessment. The authors noted that certain factors—such as enlargement of the right atrium, weak contraction of the right ventricle, and presence of thrombi in the right side of the heart—were associated with increased odds of 30-day mortality from pulmonary embolism. The results remained substantively similar even after they considered patient demographics and other clinical factors.

The large size of the study underscores the importance of echocardiography in the early assessment of patients with acute pulmonary embolism, said first author Behnood Bikdeli of Yale’s Center for Outcomes Research and Evaluation (CORE). “This is an important step forward in understanding that these patients have higher risk. The next step is to start testing more advanced strategies to determine how we can improve the outcomes of patients who present with these features,” he noted.

Read the full paper, which was presented at the European Society of Cardiology annual meeting, in the Journal of the American Heart Association.