Genetic testing after a breast cancer diagnosis can offer clues to individualized treatment decisions for a patient and her treatment team.

But many patients aren’t aware it exists and could be missing out on that opportunity, according to a new study published in Cancer.

A team at the University of Michigan Rogel Cancer Center recently sought to determine how much newly diagnosed cancer patients understand about the benefits of genetic testing after a diagnosis.

Their other objective: to find out whether a decision support tool would help improve that knowledge.

“After a woman is diagnosed with breast cancer, the relevance of information from genetic testing to her cancer changes,” says Michele Gornick, MA, PhD, a researcher at Michigan Medicine and the study’s lead author. “The question evolves from: ‘Am I going to get breast cancer?’ to: ‘How likely is it that my cancer comes back—and is my family at higher risk?’”

To gain insight, researchers enrolled 496 patients with newly diagnosed early-stage breast cancer from multiple practices in four states. Patients were randomized to view a tailored, interactive decision tool called iCanDecide or similar information on a static website.

The tool, presented as a website, was focused on informing women about their locoregional and systemic treatment. It also had a module about genetic testing that featured information about types of genetic testing, the implications of test results for treatments, and the importance of receiving genetic counseling.

Tool improves knowledge

About a month after viewing the tool, patients were surveyed to determine their knowledge about genetic testing, including the probability of carrying a BRCA1 or BRCA2 variant, the purposes and benefits of genetic testing, and the implications on cancer recurrence, treatment decisions, and family risk.

Women who used the iCanDecide tool had an 11.4% increase in genetic testing knowledge compared with those who did not, researchers found.

Still, overall rates of knowledge in both arms of the study were relatively low.

“Genetics can be hard to understand,” Gornick says. “At diagnosis, you have a lot of information coming at you that can be overwhelming. Given this, information shared during counseling may not be adequate.”

“Interactive decision tools are one possible way to enhance and improve patients’ knowledge.”