Hoerndli, a neuroscientist in the Department of Biomedical Sciences, and his lab are celebrating a Cell Reports publication that provides new insights into the intricacies of memory formation and maintenance.

"It took 12 years for this paper to come together and it was rewritten 60 times," said Hoerndli. "The last part of getting it done was figuring out how to tell this very complex story."

The brain's ability to maintain memory can decline with age. Glutamate receptors, the most prominent signalling molecule in the brain, play a key role in encoding memory. And maintaining the number of glutamate receptors present at the synapse, or junction between two nerve cells, likely determines whether or not a memory is preserved or lost.

"It was thought for a long time that this whole process was just regulated at the synapse," said Hoerndli. In 2009, he began more closely investigating how glutamate receptors get to synapses. In trying to understand how this is achieved, his team uncovered a new role for a scaffolding molecule that seemed to play an unknown, until now, part in glutamate receptor transport.

By combining previous knowledge about this scaffold and what Hoerndli recently discovered about how neurons regulate transport, his team found that there were two cell signals that were happening at a synapse. And in order for transport to occur, those signals had to happen simultaneously or in close succession.

"We essentially found how two signals that have to do with memory control transport, which ultimately affects memory," said Hoerndli. "And once we organised everything around how those two signals come together, we knew how to tell the story."

The Hoerndli lab is continuing to investigate ways various signals are controlled and work at the synapse. With greater tools and understanding of how these processes work, they hope to contribute to a more robust working body of knowledge on how to maintain memory.