Dementia linked to diet
Vanderbilt University Medical Center Research News Feb 10, 2017
There is a strong, bi–directional link between diabetes and AlzheimerÂs disease. Fiona Harrison, PhD, and colleagues tested whether the effects of obesity on diabetic status and cognitive decline in AlzheimerÂs disease are permanent or reversible.
The authors fed a common mouse model for AlzheimerÂs disease a high–fat diet for 10 months. The mice became obese and showed signs of diabetes including glucose intolerance. They developed an inflammatory response in the brain, accumulated amyloid–beta protein and exhibited cognitive deficits.
When returned to a low–fat diet, the mice rapidly lost weight, leading to correction of glucose intolerance, decreased inflammation and improved performance on behavioral tasks.
These results were published in the journal Neurobiology of Disease.
This study demonstrates that some memory deficits observed in AlzheimerÂs disease may be due to co–morbid illnesses, and not the disease itself. Lifestyle changes or pharmacologic interventions may be effective in reversing some of the cognitive decline and molecular pathologies observed in AlzheimerÂs disease.
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The authors fed a common mouse model for AlzheimerÂs disease a high–fat diet for 10 months. The mice became obese and showed signs of diabetes including glucose intolerance. They developed an inflammatory response in the brain, accumulated amyloid–beta protein and exhibited cognitive deficits.
When returned to a low–fat diet, the mice rapidly lost weight, leading to correction of glucose intolerance, decreased inflammation and improved performance on behavioral tasks.
These results were published in the journal Neurobiology of Disease.
This study demonstrates that some memory deficits observed in AlzheimerÂs disease may be due to co–morbid illnesses, and not the disease itself. Lifestyle changes or pharmacologic interventions may be effective in reversing some of the cognitive decline and molecular pathologies observed in AlzheimerÂs disease.
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