Physical fitness linked to better brain function

Healthline/Medical News Today Sep 18, 2019

The largest and most detailed study of its type concludes that there are links between physical fitness and improved cognitive performance. The researchers also show that this boost in mental powers is associated with white matter integrity.

Over recent years, there has been a great deal of research into how bodily fitness might influence the mind.

For instance, studies have concluded that physical fitness can reduce the risk of dementia, relieve depressive symptoms, and more.

There is also evidence that physical activity boosts the cognitive performance of healthy individuals, people of different ages, and participants with cognitive impairments.

Similarly, some studies have shown positive links between physical fitness and changes in brain structure.

The authors of the latest study in this field, who published their findings in Scientific Reports, note that previous studies had certain limitations.

In some cases, for instance, they did not account for variables that could play an important role.

As an example, researchers could associate low levels of physical fitness with higher blood pressure. If a study finds that high physical fitness has links with cognitive abilities, scientists could argue that in fact, it is lower blood pressure that boosts cognitive power.

The same could apply for several factors that have links with fitness, such as body mass index (BMI), blood glucose levels, and education status.

Also, most studies concentrate on only one marker of mental performance at a time, such as memory.

As the authors of the current study explain, "studies investigating associations between [physical fitness], white matter integrity, and multiple differential cognitive domains simultaneously are rare."

A fresh look at fitness and the brain

The latest experiment, carried out by scientists from University Hospital Muenster in Germany, attempts to fill in some of the gaps. Using a large sample of healthy people, the scientists retested the links between physical fitness, brain structure, and a wide range of cognitive domains.

They also wanted to ensure that they accounted for as many confounding variables as possible. Additionally, the scientists wanted to understand whether the link between cognitive ability and physical fitness was associated with white matter integrity.

White matter in the brain relays messages between disparate parts of the brain and coordinates communication throughout the organ.

To investigate, the researchers took data from the Human Connectome Project, which includes MRI brain scans from 1,206 adults with an average age of 28.8.

Some of these participants also underwent further tests. In total, 1,204 participants completed a walking test in which they walked as quickly as they could for 2 minutes. The researchers noted the distance.

A total of 1,187 participants also completed cognitive tests. In these, the scientists assessed the volunteers' memory, reasoning, sharpness, and judgment, among other parameters.

'Surprising' results

Overall, the researchers showed that individuals who performed better in the 2-minute walking test also performed significantly better in all but one of the cognitive tasks.

Importantly, this relationship was significant even after controlling for a range of factors, including BMI, blood pressure, age, education level, and sex.

The researchers also associated this cognitive improvement with higher levels of fitness with improvements in the structural integrity of white matter. The authors conclude:

"With the present work, we provide evidence for a positive relationship between [physical fitness] and both white matter microstructure as well as cognitive performance in a large sample of healthy young adults."

"It surprised us to see that even in a young population cognitive performance decreases as fitness levels drop," says lead researcher Dr. Jonathan Repple.

Dr. Repple continues, "We knew how this might be important in an elderly population, which does not necessarily have good health, but to see this happening in 30-year-olds is surprising."

"This leads us to believe that a basic level of fitness seems to be a preventable risk factor for brain health."

More questions

The current study has many strengths, not least the extensive database of MRIs. Dr. Repple explains that "normally when you are dealing with MRI work, a sample of 30 is pretty good, but the existence of this large MRI database allowed us to eliminate possibly misleading factors and strengthened the analysis considerably."

However, because researchers carried out the tests at one point in time, it is not possible to see how fitness and cognitive ability changes over time. It is also not possible to say that becoming fitter causes a boost in cognitive ability.

Future studies will need to ask whether increasing an individual's level of fitness also increases cognitive ability.

Also, by design, the current study only investigated healthy young people. How this interaction might be different in older populations or people with mental health conditions will require further work.

Taking previous studies into account, it is becoming increasingly clear that there are strong links between physical fitness and mental agility.

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