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Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368

BMC Anesthesiology Jan 13, 2019

Li WC, et al. - In this study, researchers assessed to estimate the association of the antiarrhythmic effect of additive sevoflurane to histidine-tryptophan-ketoglutarate (HTK) solution with connexin 43 (Cx43) protein. They assessed the total Cx43 level and the phosphorylation of Cx43 at Ser368 (Cx43-pS368) by Western blotting and the distribution of Cx43 by immunohistochemistry. They observed a relative increment of total Cx43 and Cx43-pS368 levels in Sevo-HTK solution. They noted no changes in transmural repolarization dispersion (TDR) with prevention of Cx43 redistribution and decreasing conduction velocity (CV). Although, they noticed shorter graft re-beating times, improvement in myocardial pathological damage as well as a reduction in number of apoptotic cells. They concluded a relation of decline in hypothermia and ischemia-induced reperfusion arrhythmias with Sevo-HTK solution to the phosphorylation of Cx43 at serine 368.
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