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Biomarkers and clinical outcomes in COPD: A systematic review and meta-analysis

Thorax Jan 11, 2019

Fermont JM, et al. - In patients with stable COPD, researchers evaluated relationships between 6 min walk distance (6MWD), heart rate, fibrinogen, C reactive protein (CRP), white cell count (WCC), interleukins 6 and 8 (IL-6 and IL-8), tumour necrosis factor-alpha, quadriceps maximum voluntary contraction, sniff nasal inspiratory pressure, short physical performance battery, pulse wave velocity, carotid intima-media thickness and augmentation index and clinical outcomes (ie, mortality, exacerbation and COPD hospital admission). Findings suggested an association of 6MWD, heart rate, CRP, fibrinogen and WCC with clinical outcomes in patients with stable COPD. According to this systematic review and meta-analysis, shorter 6MWD and elevated fibrinogen and CRP were correlated with exacerbation and shorter 6MWD, higher heart rate, CRP and IL-6 were related to hospitalisation.
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