• Profile
Close

Gallstone disease and type 2 diabetes risk: A Mendelian randomization study

Hepatology Dec 13, 2018

Wang F, et al. - In this Dongfeng-Tongji cohort study, researchers investigated the causal relationship between gallstone disease (GSD) and type 2 diabetes risk using a Mendelian randomization analysis. This observational study included 16,299 participants who were cancer-free and did have heart disease, stroke, and diabetes at baseline. The researchers used a Cox proportional hazard regression model to examine the link between GSD and the risk of type 2 diabetes. A genetic risk score (GRS) for GSD with 8 single nucleotide polymorphisms (SNPs) was constructed and tested among 7,000 participants. The multivariate-adjusted hazard ratio (HR) of type 2 diabetes risk in individuals with GSD was 1.22. Each 1-standard deviation (SD, 0.23) increment in the weighted GRS was correlated with 17% increment of type 2 diabetes risk (Odds ratio=1.17, 95% CI, 0.90-1.52), indicating a positive but not a causal connection of GSD with type 2 diabetes risk.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay