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Rural-urban differences in human papillomavirus-associated cancer trends and rates

The Journal of Rural Health Dec 12, 2018

Zahnd WE, et al. - Researchers used the North American Association of Central Cancer Registries public use data set, representing approximately 93% of the US population, to compare the rates and temporal trends for individual human papillomavirus (HPV)-associated [HPVa] cancers between rural and urban populations. For HPVa cancers, including cervical carcinomas and squamous cell carcinomas of the vagina, vulva, penis, anus, rectum, and oropharynx, they calculated age-adjusted incidence rates and rate ratios (RR; 2009-2013) and overall and annual percentage changes (APC; 1995-2013). With regard to HPVa cancers in rural populations, consistent disparities were observed. The rates of cervical, vaginal, vulvar, oropharyngeal, and anal cancer were found to be remarkably higher among rural females vs their urban peers, while rural males had higher rates of penile cancer. For nearly every cancer site, greater rate increases, or smaller rate decreases, overall and by APC, were seen in rural females and males.
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