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Association between abdominal adiposity and 20-year subsequent aortic stiffness in an initially healthy population-based cohort

Journal of Hypertension Sep 25, 2018

Chau K, et al. - In initially healthy midlife adults, researchers investigated if accelerated aortic stiffening 20 years later could be independently predicted by central and general adiposity. They conducted primary analysis to determine the link between waist circumference/BMI ratio and carotid–femoral pulse wave velocity (cfPWV) in participants from the STANISLAS cohort study (826 initially healthy participants aged 30–60 from the Lorraine region in France) with clinical and biological measurements at baseline (1994–1995) and after ≈20 years (2011–2016). They noted a positive association of waist circumference -to-BMI ratio (for 1SD increase) with higher cfPWV in a multiple linear regression model adjusted for sex, age and mean arterial pressure. Findings demonstrated that, in initially healthy midlife subjects, central adiposity (more specifically waist circumference-to-BMI ratio) could independently predict 20-year subsequent aortic stiffness.

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