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The efficacy and adverse events of testosterone replacement therapy in hypogonadal men: A systematic review and meta-analysis of randomized, placebo-controlled trials

Journal of Clinical Endocrinology & Metabolism Jun 18, 2018

Ponce OJ, et al. - Researchers determined the efficacy and adverse events associated with testosterone replacement therapy (TRT) in symptomatic hypogonadal men. From inception to 2 March 2017, Ovid Medline, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Ovid Cochrane Central Register of Controlled Trials, and Scopus were searched. Findings revealed that TRT improves sexual desire, erectile function, and sexual satisfaction but not mood, energy, or cognition in hypogonadal men. It was noted that testosterone treatment increases the risk of erythrocytosis in hypogonadal men.
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