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The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation

Pharmacogenetics and genomics Aug 15, 2017

Lloberasm N, et al. – The physicians examined the associations of single–nucleotide polymorphisms (SNPs) in drug–metabolizing enzymes (CYP3A) with tacrolimus (Tac) pharmacokinetics in renal transplant recipients. They observed a major influence of the combined CYP3A4 and CYP3A5 genotype of renal transplant recipients on the Tac dose required to reach the target exposure.
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