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Fibrin and platelet-rich composition in retrieved thrombi hallmarks stroke with active cancer

Stroke Nov 27, 2020

Fu CH, Chen CH, Lin YH, et al. - This study was carried out to assess if the histopathologic assessment of thrombi gotten from acute ischemic stroke patients undergoing endovascular treatment could discriminate cancer-related stroke from other etiologies. Researchers included a total of 152 individuals (active cancer, 19; cardioembolism, 107; large artery atherosclerosis, 26). They classified the etiology of stroke into cardioembolism, large artery atherosclerosis, and active cancer groups. They assessed percentages of fibrin/platelets, red blood cells, and white blood cells within a thrombus. A high fibrin/platelet composition was a probable indicator of cancer-related stroke in thrombi retrieved from patients undergoing endovascular treatment. A fibrin/platelet proportion of ≥65% could accurately predict cancer-related stroke.

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