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Immunohistochemical profiling of conjunctival melanocytic intraepithelial lesions, including Sox10, Hmb45, Ki67, And P16

American Journal of Ophthalmology Oct 01, 2020

Milman T, Zhang Q, Ang S, et al. - A retrospective observational case series was performed to ascertain the utility of Melan-A, SOX-10, HMB45, and p16 immunohistochemical stains in the distinction between the low-grade and high-grade conjunctival melanocytic intraepithelial lesions, either independently or as components of an immunohistochemical panel. Researchers searched institutional pathology records between 2014 and 2018 for all patients with conjunctival melanocytic intraepithelial lesions. The study included a total of 31 patients who had undergone 47 biopsies for conjunctival melanocytic lesions between 2014 and 2018. The current immunohistochemical panels have limited value in the distinction between the low-grade and high-grade intraepithelial melanocytic proliferations and need to be used judiciously, although the stains for melanocytic markers Melan-A and SOX-10 facilitate the assessment of melanocytic intraepithelial lesions.

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