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Obesity‐related traits and the development of rheumatoid arthritis – Evidence from genetic data

Arthritis & Rheumatology Sep 26, 2020

Tang B, Shi H, Alfredsson L, et al. - Researchers performed a genetic correlation analysis and two‐sample Mendelian randomization study, using genome‐wide genetic data based on > 850,000 individuals of European ancestry to understand the association between obesity‐related traits and risk of rheumatoid arthritis (RA). Researchers obtained summary statistics from the hitherto largest GWAS conducted for body mass index, waist‐to‐hip ratio, waist‐to‐hip ratio adjusted for BMI, and RA. The cross‐trait linkage disequilibrium score regression and ρ‐HESS were conducted to evaluate the genetic association between pairs of traits (causal overlap). It was shown that genetically predicted BMI significantly elevates RA risk. Future trials are required to evaluate the biological mechanisms underlying such a link.

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