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Patterns of cancer family history and genetic counseling eligibility among African Americans with breast, prostate, lung, and colorectal cancers: A Detroit Research on Cancer Survivors cohort study

Cancer Aug 09, 2020

Purrington KS, Schwartz AG, Ruterbusch JJ, et al. - Family history (FH) is one of the strongest risk factors for many common cancers and determines cancer genetic counseling (CGC) eligibility, so researchers used the Detroit Research on Cancer Survivors (ROCS) cohort to assess cancer family history (FH) among African Americans with invasive breast cancer, prostate cancer, lung cancer, or colorectal cancer (CRC). Through logistic regression, connections between cancer type, site‐specific FH, and meeting national guidelines for cancer genetic counseling (CGC) were analyzed. At least 1 first‐degree relative or grandparent with cancer was reported by 71% of the 1,500 ROCS participants included in this study. Among participants with the same diagnosis, FHs of breast cancer, CRC, lung cancer, and prostate cancer were commonly seen. National CGC guidelines were met by 47% of participants, and CGC criteria was met by 24.4% on the basis of their cancer FH alone. For participants with prostate cancer vs breast cancer, FH was especially important in assessing eligibility for CGC. Breast and prostate cancer FH–defined clusters were common among all participants in clustering analyses. They also saw clustering of CRC and breast cancer FHs. High rates of cancer FH were seen in ROCS participants. Interventions to increase referrals and CGC uptake among African American people are needed, as shown by the high eligibility rate among ROCS participants for CGC.

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