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Digoxin initiation and outcomes in patients with heart failure (HFrEF and HFpEF) and atrial fibrillation

American Journal of Medicine Jul 01, 2020

Singh S, Moore H, Karasik PA, et al. - This study was intended to present Digoxin initiation and outcomes in patients with heart failure (HFrEF and HFpEF) and atrial fibrillation. Researchers performed an observational propensity score-matched study of pre-discharge digoxin initiation in 1,768 hospitalized patients with heart failure and atrial fibrillation in Medicare-linked OPTIMIZE-HF registry, balanced on 56 baseline characteristics (mean age, 79 years; 55% women; 7% African American). They calculated Hazard ratios and 95% confidence intervals (CIs) for outcomes for the 884 patients initiated on digoxin compared with 884 not initiated on digoxin. The data demonstrate that initiation of digoxin was correlated with a lower risk of heart failure readmission but had no relationship with mortality among hospitalized older patients with HFrEF and HFpEF and atrial fibrillation.

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