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Baseline characteristics of patients with atypical haemolytic uraemic syndrome (aHUS ): The Australian cohort in a global aHUS registry

Nephrology Jun 27, 2020

Soraru J, Isbel N, Wong G, et al. - Researchers used the Global aHUS Registry to determine the baseline features as well as treatment of Australian patients who received a diagnosis of atypical haemolytic uraemic syndrome (aHUS). For comparison, the global cohort (n = 1,688) was used. They noted that among patients diagnosed with aHUS in Australia, almost two‐thirds were female and over 80% were Caucasians, with similar proportions documented in the global cohort. A history of autoimmune disease or cancer, entities that have been related to secondary HUS, was found in less than 6% of patients in the Australia and global cohorts. A kidney transplant was received by 26% and eculizumab by 68% of patients in the Australian cohort. Most commonly, kidneys were involved. In the Australian cohort, the most frequent pathogenic complement gene variant was complement factor H. Overall, in a selected population of Australian children and adults suffering from aHUS, reported to the registry, region‐specific disease features were corroborated as well as described using data from the aHUS registry.

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