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Evaluation of human papilloma virus in semen as a risk factor for low sperm quality and poor in vitro fertilization outcomes: A systematic review and meta-analysis

Fertility and Sterility May 09, 2020

Weinberg M, Nahshon CSS, Feferkorn I, et al. - Researchers conducted a systematic review and meta-analysis in order to ascertain the influence of human papilloma virus (HPV) sperm infection on sperm parameters and in vitro fertilization (IVF) outcomes. Searching Medline(R), PubMed, Embase, Web of Science, Scopos, and the Cochrane Library, they identified 16 studies for inclusion in this meta-analysis. Per findings, HPV infection negatively influence sperm concentration, motility, and morphology. In further subgroup and categorical analysis, the clinical significance of impaired sperm motility in HPV-infected sperm was confirmed, although careful analysis of the sperm count and morphology is a requisite. In reviewed studies, lower pregnancy rate and increased miscarriage rate were reported in couples with HPV-infected sperm. Men with HPV sperm infection and couples undergoing IVF.

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