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Novel coronavirus pneumonia (COVID-19) progression course in 17 discharged patients: Comparison of clinical and thin-section CT features during recovery

Clinical Infectious Diseases Apr 03, 2020

Han X, Cao Y, Jiang N, et al. - Researchers retrospectively analyzed 17 discharged patients for the evolution of clinical features and thin-section CT imaging of novel coronavirus pneumonia (COVID-19). They obtained serial thin-section CT scans during recovery and longitudinal changes of clinical parameters and documented CT pattern during 4 weeks since admission. Within the first 2 weeks, a marked improvement of fever, lymphocytes count, C-reactive protein and erythrocyte sedimentation rate was observed. However, a rapid increase in the mean CT score was observed from first to third week; a top score of 8.2 was obtained in the second week. The main CT pattern was ground-glass opacities (GGO,76.5%) during the first week. A decrease in the frequency of GGO (52.9%) was noted in the second week. They noted consolidation and mixed patterns (47.0%) in the 2nd week. Thereafter, dissipation of consolidations into GGO was generally observed and increase in the frequency of GGO was noted in the third week (76.5%) and 4th week (71.4%). Opacities were mainly located in the peripheral (76.5%), subpleural (47.1%) zones of the lungs, and presented as focal (35.3%) or multifocal (29.4%) in the first week and became more diffuse in the second (47.1%) and third week (58.8%), then displayed decreased extent in forth week (50%). Findings thereby suggest that within the first two weeks since admission, the progression course of CT pattern vs the clinical parameters was later; however, in the forth week, both clinical and radiologic features had a synchronized improvement.

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