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Impact of time to second transurethral resection on oncological outcomes of patients with high-grade T1 bladder cancer treated with intravesical Bacillus Calmette–Guerin

World Journal of Urology Feb 20, 2020

Calò B, Falagario U, Sanguedolce F, et al. - This study was conducted to assess the effect of time to restaging transurethral resection (Re-TUR) on recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS) of individuals with high-grade T1 bladder cancer (BC) treated with intravesical Bacillus Calmette–Guerin (BCG). A total of 269 high-grade T1 BC patients were eligible for the analysis. The prospectively maintained NMIBC databases were questioned to distinguish individuals with high-grade T1 BC who underwent Re-TUR before receiving intravesical BCG treatment (induction + 1-year maintenance). Individuals were categorized into three groups based on time to Re-TUR. Researchers applied Kaplan–Meier plots to determine differences in RFS, PFS, and CSS. They further applied multivariate Cox regression analysis to evaluate the effect of time to Re-TUR on oncological outcomes. This is the first research examining the role of time to Re-TUR in a homogeneous population of individuals with high-grade T1 BC who received complete BCG treatment. Since time to Re-TUR did not significantly affect oncological outcomes, the study challenged the concept the sooner the Re-TUR the better.
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