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Diverse and highly cross-reactive T-cell responses in ragweed allergic patients independent of geographical region

Allergy Jan 16, 2020

Würtzen PA, Hoof I, Christensen LH, et al. - Given ragweed often induces seasonal allergies in North America and Europe, and allergic symptoms are induced by various associated ragweed species with different geographical distribution in the United States, and in view of previously identified cross-reactivity towards related ragweed species of IgE and treatment-induced IgG4, researchers focused on the underlying T-cell cross-reactivity in this study done with 20 American ragweed allergic patients and 11 American and 14 Slovakian ragweed allergic donors. Findings revealed the involvement of T-cell epitopes of multiple allergens/isoallergens in the diverse T-cell responses in ragweed allergic people. High cross-reactivity of T-cell lines to epitopes of related ragweed species, without any apparent geographical response bias, was also shown. These findings support that different ragweed species can be regarded as an allergen homology group with Amb a as the representative species concerning diagnosis as well as allergy immunotherapy.
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