Keita M, Keita S, Diallo B, et al. - Since the discovery of the Ebola virus in 1976, the 2013–2016 Ebola virus disease (EVD) outbreak was identified to be the largest outbreak. Identifying the medical needs of survivors and the risk for virus reintroduction, WHO emphasized the necessity for an intensive integrated program ideally a program that could be integrated into existing routine health services and facilities. Hence, the national program coordinating EVD in Guinea, in collaboration with WHO and partners, developed and implemented a survivors’ monitoring program (called SA-Ceint, derived from the French phrase “cordon sanitaire-based active surveillance”). Researchers here reported the experience of setting up and implementing this nationwide active surveillance program with EVD survivors in Guinea. Implementation of an alert system for early detection of Ebola resurgence was done among survivors at the end of the 2013–2016 Ebola virus disease outbreak in Guinea. Survivors were directed to notify health alerts in their household and provide body fluid specimens for laboratory testing. A total of 1,075 (88%) of 1,215 survivors participated in the system during April–September 2016; at a median of 16 months following discharge, follow up was performed (interquartile range 14–18 months). Of these, 784 behaved as focal points and inscribed 1,136 alerts (including 4 deaths among survivors). Testing of > 1 semen specimen was done in a total of 372 (91%) of 408 eligible survivors. Positivity was reported up to 512 days after discharge in 5 samples from 4 survivors among 817 semen specimens. Positivity was not reported in any of the lochia (0/7) or breast milk (0/69) specimens. These findings support performing long-term monitoring of survivors’ semen samples in an Ebola-affected country.