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Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients

Nephrology Dialysis Transplantation Jan 16, 2020

von Moos S, Segerer S, Davenport A, et al. - Since improved patient care and decreased mortality related to fluid overload (FO) can be ensured via improved understanding and evaluation of the complex physiology of volume regulation in haemodialysis (HD) patients, therefore, researchers investigated FO-related biomarkers among 184 peptides related to cardiovascular disease in a cohort of 30 HD patients. They identified seven peptides showing a positive correlation to FO [NT-proBNP, B-type natriuretic peptide (BNP), vascular endothelial growth factor D (VEGFD), tumour necrosis factor-related apoptosis-inducing ligand receptor 2, growth differentiation factor 15, tumour necrosis factor ligand superfamily member 13B, chitinase-3-like protein 1], as well as five peptides that showed negative correlation to FO (leptin, renin, epidermal growth factor receptor, interleukin-1 receptor antagonist, myeloblastin). Higher 1-year all-cause mortality was noted in patients with high BNP, FO (defined by bioimpedance analysis) and high VEGFD, but not with high vascular endothelial growth factor C. Based on the findings, VEGFD was recognized as a new FO-related biomarker having unique diagnostic and prognostic properties.
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