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Diet-related metabolomic signature of long-term breast cancer risk using penalized regression: An exploratory study in the SU.VI.MAX cohort

Cancer Epidemiology, Biomarkers & Prevention Jan 13, 2020

Lécuyer L, Dalle C, Lefevre-Arbogast S, et al. - In an exploratory study, researchers investigated diet-associated metabolites distinguishing women at higher risk of breast cancer via utilizing untargeted metabolomics. From a nested case-control study within the Supplémentation en Vitamines et Minéraux Antioxydants cohort, they analyzed baseline plasma samples from 200 patients with incident breast cancer and matched controls using untargeted LC-MS. They selected 595 ions as candidate diet–related metabolites, and identified a diet-related plasma metabolic signature including exogenous, steroid metabolites, and microbiota-related compounds linked with long-term breast cancer risk. Plasma samples from women who subsequently suffered breast cancer exhibited a lower level of piperine (a compound from pepper) and higher levels of acetyltributylcitrate (an alternative plasticizer to phthalates), pregnene-triol sulfate (a steroid sulfate), and 2-amino-4-cyano butanoic acid (a metabolite linked to microbiota metabolism).

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