Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case-control study
International Journal of Cancer Dec 26, 2019
Pottegård A, et al. - In this Danish nationwide case-control study including histologically confirmed bladder cancer cases (2000-2015; n = 12,271) and age- and gender-matched cancer-free controls, researchers examined the link between urinary tract infections (UTIs), indicated by use of specific antibiotics, and risk of squamous cell carcinomas (SCC) of the bladder. They found 333 SCC cases (2.7% of all bladder cancers). They found the link of high-use (≥ 10 prescriptions) of UTI-specific antibiotics, vs no use (0-1 prescriptions), with SCC with an OR of 11.4 and a definite dose-response pattern. Following adjustment for use of UTI-specific antibiotics, they found no link between phenoxymethylpenicillin (an antibiotic not used against UTIs) use and SCC. They also identified no association between UTI-specific antibiotic use and urothelial carcinomas. Overall, findings revealed a strong, dose-dependent, as well as a specific link of common UTIs with the risk of SCC of the bladder.Go to Original
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