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Prognostic value of serum uric acid in hospitalized heart failure patients with preserved ejection fraction (from the Japanese nationwide multicenter registry)

The American Journal of Cardiology Dec 14, 2019

Kobayashi Y, Omote K, Nagai T, et al. - Researchers investigated if there may be a link between serum uric acid (UA) level on admission and subsequent mortality in hospitalized patients with heart failure patients with preserved ejection fraction (HFpEF). From the HFpEF-specific multicenter registry, they analyzed 516 consecutive hospitalized HFpEF (LVEF ≥ 50%) patients with decompensated heart failure with available serum UA data on admission. The death of 90 (17%) patients was reported during a median follow-up of 749 days. They noted a significant link of higher serum UA level with an increased incidence of all-cause death. Among the groups, the incidence of all-cause death was found to be the highest among patients with higher serum UA (≥ 6.6 mg/dL, median) and plasma B-type natriuretic peptide (≥ 401.2 pg/mL, median) levels. In hospitalized HFpEF patients, higher admission serum UA was identified as an independent determinant of mortality. For further risk stratification in these patients, it may be important to evaluate the admission serum UA level.
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