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The predictive value of PaO2/FIO2 and additional parameters for in-hospital mortality in patients with acute pulmonary embolism: An 8-year prospective observational single-center cohort study

BMC Pulmonary Medicine Dec 14, 2019

Wang Y, Yang H, Qiao L, et al. - Given the importance of rapid stratification and suitable treatment on admission for saving lives of patients with acute pulmonary embolism (PE), researchers performed this prospective single-center observational cohort study to examine the link between the arterial partial pressure of oxygen/fraction of inspired oxygen (PaO2/FIO2) ratio and in-hospital mortality in this patient population. They also investigated the optimal cutoff value of PaO2/FIO2, and explored whether in-hospital mortality could be predicted by this value, which is quick and easy to obtain on admission. They noted differences in body mass index, history of cancer, PaO2/FiO2 value, pulse rate, cardiac troponin I level, lactate dehydrogenase level, white blood cell count, D-dimer level, and risk stratification measurements between survivors and non-survivors. For mortality prediction, the optimal cutoff value of PaO2/FiO2 was identified to be 265 (AUC = 0.765). This implies that valuable information regarding patients’ in-hospital prognosis may be acquired on admission by a simple determination of the PaO2/FiO2 ratio at < 265. Predictors of in-hospital mortality of acute PE were PaO2/FiO2 ratio < 265, history of cancer, and risk stratification.
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