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Kidney function decline among black patients with sickle cell trait and sickle cell disease: An observational cohort study

Journal of the American Society of Nephrology Dec 14, 2019

Olaniran KO, Allegretti AS, Zhao SH, et al. - In order to better understand the trajectory as well as predictors of kidney function decline in patients with sickle cell trait and sickle cell disease, researchers performed this multicenter, observational analysis utilizing registry data (obtained January 2005 through June 2018). Participants were adult black patients having sickle cell trait or disease (exposures) or normal hemoglobin phenotype (reference) status (determined by electrophoresis) and at least 1 year of follow-up and three eGFR values. Employing linear mixed models, they assessed the difference in the mean alteration in eGFR per year. They found the link of sickle cell trait and disease with faster eGFR decline in black patients, with a faster decline in sickle cell disease. They also identified that low hemoglobin S was related to faster eGFR decline in sickle cell trait but possibly confounded by concurrent hemoglobinopathies.
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