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Severity of hypertension mediates the association of hyperuricemia with stroke in the REGARDS case cohort study

Hypertension Dec 13, 2019

Chaudhary NS, Bridges SL, Saag KG, et al. - Since earlier investigations do not broadly support hyperuricemia as a risk factor for stroke and other cardiovascular diseases, therefore, researchers examined the link between hyperuricemia and ischemic stroke (≈900 cases) employing a large data set from the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). They estimated the link of serum urate level ≥ 6.8 mg/dL (ie, hyperuricemia) and 6.0 to < 6.8 mg/dL vs < 6.0 mg/dL (reference) with incident stroke, using a case-cohort design (incident stroke cases and randomly selected cohort participants) and weighted Cox-proportional hazard models. The analyses performed were stratified by race, gender, and age. Based on the findings, the experts concluded hyperuricemia as a likely risk factor for stroke. This link was substantially attenuated by apparent treatment-resistant hypertension and the number of antihypertensive, indicating that severe hypertension may be a mediator.
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